SYNTHESIS OF (R) AND (S)-3-AMINOQUINUCLIDINE FROM 3-QUINUCLIDINONE AND (S) AND (R)-1-PHENETHYLAMINE

被引：17

作者：

LANGLOIS, M

MEYER, C

SOULIER, JL

机构：

[1] CNRS-CERCOA, F-94320, THIAIS

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 13期

关键词：

D O I：

10.1080/00397919208021320

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (R) and (S)-3-amino quinuclidine, an important building block for the synthesis of chiral 5-HT3 serotonin receptor antagonists, is described. The key reaction is the reduction by NaBH4 of the imine prepared from the 3-quinuclidinone and chiral (S) or (R)-1-phenethylamine.

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页码：1895 / 1911

页数：17

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