Multislice computed tomography and magnetic resonance imaging for the assessment of reperfused acute myocardial infarction

被引:154
作者
Baks, Timo
Cademartiri, Filippo
Moelker, Amber D.
Weustink, Annick C.
van Geuns, Robert-Jan
Mollet, Nico R.
Krestin, Gabriel P.
Duncker, Dirk J.
de Feyter, Pim J.
机构
[1] Erasmus Univ, Med Ctr, Dept Radiol, Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr, Dept Cardiol, Thoraxctr, Rotterdam, Netherlands
关键词
D O I
10.1016/j.jacc.2006.02.059
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
OBJECTIVES We evaluated the accuracy of in vivo delayed-enhancement multistice computed tomography (DE-MSCT) and delayed-enhancement magnetic resonance imaging (DE-MRI) for the assessment of myocardial infarct size using postmortem triphenyltetrazolium chloride (TTC) pathology as standard of reference. BACKGROUND The diagnostic value of DE-MSCT for the assessment of acute reperfused myocardial infarction is currently unclear. METHODS In 10 domestic pigs (25 to 30 kg), the circumflex coronary artery was balloon-occluded for 2 h followed by reperfusion. After 5 days (3 to 7 days), DE-MRI (1.5-T) was performed 15 min after administration of 0.2 mmol/kg gadolinium-DTPA using an inversion recovery gradient echo technique. On the same day, DE-MSCT (64-slice) was performed 15 min after administration of 1 gI/kg of iodinated contrast material. One day after imaging, hearts were excised, sectioned in 8 min short-axis slices, and stained with TTC. Infarct size was defined as the hyperenhanced area on DE-MSCT and DE-MRI images and the TTC-negative area on TTC pathology slices. Infarct size was expressed as percentage of total slice area. RESULTS Infarct size determined by DE-MSCT and DE-MRI showed a good 2 correlation with infarct size assessed with TTC pathology (R-2 = 0.96 [p < 0.001] and R = 0.93 [p < 0.001], respectively). The correlation between DE-MSCT and DE-MRI was also good (W = 0.96; p < 0.001). The relative difference in CT attenuation value of infarcted myocardium compared to remote myocardium was 191 +/- 18%. The relative MR signal intensity between infarcted myocardium and remote myocardium was 554 +/- 156%. CONCLUSIONS We demonstrated that DE-MSCT can assess acute reperfused myocardial infarction in good agreement with in vivo DE-MRI and TTC pathology.
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页码:144 / 152
页数:9
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