Clinicopathological significance of PI3K, Akt and survivin expression in gastric cancer

被引：68

作者：

Gu, Yongjuan ^{[1
]}

Jin, Shidai ^{[1
]}

Wang, Feng ^{[2
]}

Hua, Yibin ^{[2
]}

Yang, Li ^{[2
]}

Shu, Yongqian ^{[1
]}

Zhang, Zhihong ^{[3
]}

Guo, Renhua ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Med Oncol, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Surg, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Pathol, Nanjing, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2014年 / 68卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Gastric cancer; PI3K/Akt/survivin; Immunohistochemistry; SIGNALING PATHWAY; TUMOR-GROWTH; ADENOCARCINOMA; METASTASIS; APOPTOSIS; ADJUVANT; CELLS; GENE;

D O I：

10.1016/j.biopha.2014.03.010

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Background: Gastric cancer is the second leading cause of cancer-related deaths worldwide, and is characterized by invasion and metastasis. Increasing attention is being focused on discovering molecular markers for diagnosis and prognosis. Our objective was to evaluate PI3K, Akt and survivin protein expression in gastric cancer, and their correlations with clinicohistological features and prognosis in patients with gastric cancer. Methods: Tissue samples were obtained from 70 patients with gastric cancer patients and 20 patients with normal gastric mucosa. The protein levels of PI3K, Akt and survivin were evaluated by immunohistochemistry. Statistical analyses were performed to establish the correlations between their expressions and patients' clinicopathologic characteristics. Results: The positive expression rates of PI3K, Akt and survivin were significantly higher in the gastric cancer tissues compared to normal gastric mucosa (P < 0.05). Expression levels of PI3K, Akt and survivin proteins were significantly correlated with TNM stage, differentiation grade, lymph node metastasis and metastases to other organs (P < 0.05). Cooperative relationships were identified between PI3K and Akt, and PI3K and survivin (P < 0.01), suggesting the involvement of the PI3K/Akt/survivin signaling pathway in the tumorigenesis of gastric cancer. Conclusions: Protein expression of PI3K, Akt and survivin were significantly associated with the development, progression and metastasis of gastric cancer and may have value as diagnostic and prognostic markers in gastric cancer. (C) 2014 Published by Elsevier Masson SAS.

引用

页码：471 / 475

页数：5

共 26 条

[1]

Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival [J].