The aryl hydrocarbon receptor in immunity

被引：379

作者：

Esser, Charlotte ^{[1
]}

Rannug, Agneta ^{[2
]}

Stockinger, Brigitta ^{[3
]}

机构：

[1] Inst Umweltmed Forsch, D-40225 Dusseldorf, Germany

[2] Karolinska Inst, Inst Environm Med, Inst Miljomed, S-17177 Stockholm, Sweden

[3] Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 09期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

NF-KAPPA-B; AH RECEPTOR; IN-VIVO; ARYLHYDROCARBON RECEPTOR; TRYPTOPHAN PHOTOPRODUCT; METABOLIZING-ENZYMES; GENE-TRANSCRIPTION; CYP1A INDUCTION; CULTURE-MEDIUM; HIGH-AFFINITY;

D O I：

10.1016/j.it.2009.06.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Low-molecular-weight chemicals or xenobiotics might contribute to the increasing prevalence of allergies and autoimmunity. Certain chemicals can alter immune responses via their action on the cytosolic transcription factor aryl hydrocarbon receptor (AhR). AhR recognizes numerous small xenobiotic and natural molecules, such as dioxin and the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole. Although AhR is best known for mediating dioxin toxicity, knockout studies have indicated that AhR also plays a role in normal physiology, including certain immune responses. In particular, Th17 cells and dendritic cells express high levels of AhR. We review here current evidence for the physiological role of AhR in the immune system, focussing in particular on T-cell biology.

引用

收藏

页码：447 / 454

页数：8

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