Natural killer cells and dendritic cells: Rendezvous in abused tissues

被引：550

作者：

Moretta, A ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

[2] Univ Genoa, Ctr Eccellenza Ric Biomed, I-16132 Genoa, Italy

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 12期

关键词：

D O I：

10.1038/nri956

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells and dendritic cells (DCs) are two types of specialized cell of the innate immune system, the reciprocal interaction of which results in a potent, activating cross-talk. For example, DCs can prime resting NK cells, which, in turn, after activation, might induce DC maturation. However, NK cells negatively regulate the function of DCs also by killing immature DCs in peripheral tissues. Moreover, a subset of NK cells, after migration to secondary lymphoid tissues, might have a role in the editing of mature DCs based on the selective killing of mature DCs that do not express optimal surface densities of MHC class I molecules. So, cognate interactions between NK cells and DCs provide a coordinated mechanism that is involved not only in the regulation of innate immunity, but also in the promotion of appropriate downstream adaptive responses for defence against pathogens.

引用

页码：957 / 964

页数：8

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