Teicoplanin therapy for Staphylococcus aureus septicaemia:: relationship between pre-dose serum concentrations and outcome

被引：114

作者：

Harding, I

MacGowan, AP ^{[1
]}

White, LO

Darley, ESR

Reed, V

机构：

[1] N Bristol NHS Trust, Bristol Ctr Antimicrobial Res & Evaluat, Bristol BS10 5NB, Avon, England

[2] Univ Bristol, Dept Med Microbiol, Southmead Hosp, Bristol BS10 5NB, Avon, England

[3] Micron Res Ltd, Upwell PE14 9AR, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 45卷 / 06期

关键词：

D O I：

10.1093/jac/45.6.835

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Logistic regression analysis was performed on data drawn from a clinical trials database for Staphylococcus aureus septicaemia treated with teicoplanin. Variables analysed were age, body weight, mean pre-dose and post-dose serum teicoplanin concentrations, mean dose (mg or mg/kg body weight) and combination versus monotherapy. Only two variables correlated with clinical outcome at a significance level better than 0.05: age (P = 0.012) and mean pre-dose serum concentration (P = 0.010). The probability of successful treatment declined with age and increased with mean pre-dose serum concentration.

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页码：835 / 841

页数：7

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