Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

被引：1656

作者：

DeFronzo, Ralph A. ^{[1
]}

Tripathy, Devjit ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

来源：

DIABETES CARE | 2009年 / 32卷

关键词：

IMPAIRED GLUCOSE-TOLERANCE; GLYCOGEN-SYNTHASE ACTIVITY; BETA-CELL DYSFUNCTION; CONSCIOUS NORMAL RATS; STRONG FAMILY-HISTORY; ORAL GLUCOSE; PHYSIOLOGICAL HYPERINSULINEMIA; TRANSPORT-PHOSPHORYLATION; SECRETORY DYSFUNCTION; RECEPTOR SUBSTRATE-1;

D O I：

10.2337/dc09-S302

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页码：S157 / S163

页数：7

共 65 条

[1]

Contributions of β-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose [J].

Abdul-Ghani, MA ;

Tripathy, D ;

DeFronzo, RA .

DIABETES CARE, 2006, 29 (05) :1130-1139

[2]

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance [J].

Abdul-Ghani, Muhammad A. ;

Muller, Florian L. ;

Liu, Yuhong ;

Chavez, Alberto O. ;

Balas, Bogdan ;

Zuo, Pengou ;

Chang, Zhi ;

Tripathy, Devjit ;

Jani, Rucha ;

Molina-Carrion, Marjorie ;

Monroy, Adriana ;

Folli, Franco ;

Van Remmen, Holly ;

DeFronzo, Ralph A. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 295 (03) :E678-E685

[3]

Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes [J].

Bajaj, M ;

Suraamornkul, S ;

Kashyap, S ;

Cusi, K ;

Mandarino, L ;

DeFronzo, RA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (09) :4649-4655

[4]

CORRELATION BETWEEN MUSCLE GLYCOGEN-SYNTHASE ACTIVITY AND INVIVO INSULIN ACTION IN MAN [J].

BOGARDUS, C ;

LILLIOJA, S ;

STONE, K ;

MOTT, D .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (04) :1185-1190

[5]

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes [J].

Bouzakri, K ;

Roques, M ;

Gual, P ;

Espinosa, S ;

Guebre-Egziabher, F ;

Riou, JP ;

Laville, M ;

Le Marchand-Brustel, Y ;

Tanti, JF ;

Vidal, H .

DIABETES, 2003, 52 (06) :1319-1325

[6]

Insulin resistance differentially affects the PI3-kinase- and MAP kinase-mediated signaling in human muscle [J].

Cusi, K ;

Maezono, K ;

Osman, A ;

Pendergrass, M ;

Patti, ME ;

Pratipanawatr, T ;

DeFronzo, RA ;

Kahn, CR ;

Mandarino, LJ .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (03) :311-320

[7]

DEFRONZO R A, 1987, Diabetes Metabolism Reviews, V3, P415

[8]

FASTING HYPERGLYCEMIA IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS - CONTRIBUTIONS OF EXCESSIVE HEPATIC GLUCOSE-PRODUCTION AND IMPAIRED TISSUE GLUCOSE-UPTAKE [J].

DEFRONZO, RA ;

FERRANNINI, E ;

SIMONSON, DC .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (04) :387-395

[9]

DeFronzo RA, 1997, DIABETES REV, V5, P177

[10]

DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214

← 1 2 3 4 5 6 7 →