Di(ethylene glycol) vinyl ether: a highly efficient deactivating reagent for olefin metathesis catalysts

被引：26

作者：

Liu, Weidong ^{[1
]}

Nichols, Paul J. ^{[1
]}

Smith, Nathan ^{[2
]}

机构：

[1] Array BioPharma Inc, Dept Proc Chem, Boulder, CO 80301 USA

[2] Univ Colorado, Boulder, CO 80309 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 45期

关键词：

Metathesis; Scavenger; RCM; Fisher carbene; Ruthenium; RING-CLOSING METATHESIS; HCV PROTEASE INHIBITOR; BY-PRODUCTS; RUTHENIUM; COMPLEXES; REMOVAL; ISOMERIZATION; BILN-2061; SCALE;

D O I：

10.1016/j.tetlet.2009.08.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A highly efficient method for deactivating commonly used olefin metathesis catalysts is described. Inexpensive and commercially available di(ethylene glycol) vinyl ether is found to quench both first- and second-generation Grubbs' carbenes in less than 10 min at room temperature. The resulting ruthenium byproducts are readily removed by silica gel purification. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6103 / 6105

页数：3

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