Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

被引：417

作者：

Li, Yu-Ling ^{[1
,2
]}

Zhu, Li ^{[3
]}

Liu, Zhaozhong ^{[1
,2
]}

Cheng, Ru ^{[1
,2
]}

Meng, Fenghua ^{[1
,2
]}

Cui, Jing-Hao ^{[3
]}

Ji, Shun-Jun ^{[1
,2
]}

Zhong, Zhiyuan ^{[1
,2
]}

机构：

[1] Soochow Univ, Biomed Polymers Lab, Suzhou 215123, Peoples R China

[2] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[3] Soochow Univ, Coll Pharm, Suzhou 215123, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 52期

基金：

中国国家自然科学基金;

关键词：

antitumor agents; cross-linking; drug delivery; nanoparticles; polymers; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; POLYMERIC MICELLES; LIPOIC ACID; RELEASE; THERAPEUTICS; ENVIRONMENT; HYDROGELS; VESICLES; SYSTEMS;

D O I：

10.1002/anie.200904260

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Getting in there: Efficient intracellular delivery of anticancer drugs is achieved by using reversibly cross-linked dextran nanoparticles, which are rapidly destabilized under reductive environments that mimic those of the intracellular compartments. These nanoparticles show high drug loading efficiency and reductiontriggered release of doxorubicin in vitro as well as inside tumor cells, particularly to the cell nucleus (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9914 / 9918

页数：5

共 48 条

[1]

Drug delivery systems: Entering the mainstream [J].