Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants

被引：10

作者：

Notter, Robert H.

Wang, Zhongyi

Wang, Zhengdong

Davy, Jason A.

Schwan, Adrian L. ^{[1
]}

机构：

[1] Univ Guelph, Dept Chem, Guelph, ON N1G 2W1, Canada

[2] Univ Rochester, Dept Pediat, Rochester, NY 14642 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 01期

关键词：

lung surfactant therapy; phosphoglycerols; organic synthesis; surface tension;

D O I：

10.1016/j.bmcl.2006.09.083

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs wore measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：113 / 117

页数：5

共 45 条

[21] INFLUENCE OF CALCIUM ON PHOSPHATIDYLGLYCEROL - 2 SEPARATE LAMELLAR STRUCTURES [J].