The EZH2 polycomb transcriptional repressor - a marker or mover of metastatic prostate cancer?

被引：92

作者：

Sellers, WR ^{[1
]}

Loda, M

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med Oncol,Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

来源：

CANCER CELL | 2002年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(02)00187-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The recent finding of overexpression of the polycomb group transcriptional repressor EZH2 in prostate cancer raises the possibility that transcriptional regulation at the chromatin level may play a role in the development of the metastatic phenotype and suggests new avenues of exploration with respect to patient stratification and therapeutics.

引用

页码：349 / 350

页数：2

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