Cyclodextrins to increase the utility of enzymes in organic synthesis

被引：33

作者：

Harper, JB

Easton, CJ ^{[1
]}

Lincoln, SF

机构：

[1] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia

[2] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia

来源：

CURRENT ORGANIC CHEMISTRY | 2000年 / 4卷 / 04期

关键词：

D O I：

10.2174/1385272003376247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of cyclodextrins to facilitate enzyme-catalysed processes is reviewed. The effects of the host molecules are discussed with specific attention paid to increasing the availability of insoluble substrates, reducing substrate inhibition and limiting product inhibition. Tn each case, the effects of the cyclodextrins are interpreted in terms of the formation of inclusion complexes. It is thus demonstrated that cyclodextrins can be used in a rational fashion to increase the utility of enzymes in organic synthesis.

引用

页码：429 / 454

页数：26

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