Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids:: Key intermediates for H3 histamine receptor ligands

被引：10

作者：

Braña, MF

Guisado, C

Alguacil, LF

Garrido, E

Pérez-García, C

Ruiz-Gayo, M

机构：

[1] Univ San Pablo CEU, Dept Ciencias Quim, Secc Quim Organ & Farmaceut, Madrid 28668, Spain

[2] Univ San Pablo CEU, Dept Farmacol Tecnol & Desarrollo Farmaceut, Secc Farmacol & Toxicol, Madrid 28668, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(02)00793-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new synthetic methodology to provide cis-2-(1H-imidazol-4-yl)-cyclopropane carboxylic acids is described. These cyclopropanes are useful for the preparation of novel H-3 receptor agents. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3561 / 3563

页数：3

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