Ceramide in apoptosis: an overview and current perspectives

被引：639

作者：

Pettus, BJ ^{[1
]}

Chalfant, CE ^{[1
]}

Hannun, YA ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2002年 / 1585卷 / 2-3期

关键词：

ceramide; apoptosis; topology; metabolism; analysis; mass spectrometry; binding effector; ceramide-activated protein phosphatase;

D O I：

10.1016/S1388-1981(02)00331-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent years have witnessed significant advances in the understanding of the role of ceramide in apoptosis. This review summarizes these recent findings and discusses insights from studies of ceramide metabolism, topology, and effector actions. The recent identification of several genes for enzymes of ceramide metabolism, the development of mass spectrometric methods for ceramide analysis, and the increasing molecular and pharmacological tools to probe ceramide metabolism and function promise an accelerated phase in defining the molecular and biochemical details of the role of ceramide in apoptosis. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：114 / 125

页数：12

共 155 条

[41] Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain [J].

El Bawab, S ;

Bielawska, A ;

Hannun, YA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) :27948-27955

[42] Interleukin-1β induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells [J].

Franzen, R ;

Pautz, A ;

Bräutigam, L ;

Geisslinger, G ;

Pfeilschifter, J ;

Huwiler, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) :35382-35389

[43] Purification and characterization of ceramide-activated protein phosphatases [J].

Galadari, S ;

Kishikawa, K ;

Kamibayashi, C ;

Mumby, MC ;

Hannun, YA .

BIOCHEMISTRY, 1998, 37 (32) :11232-11238

[44]

GarciaRuiz C, 1997, J BIOL CHEM, V272, P11369

[45]

Garzotto M, 1998, CANCER RES, V58, P2260

[46]

Goldkorn T, 1998, J CELL SCI, V111, P3209

[47] CD95 signaling via ceramide-rich membrane rafts [J].

Grassmé, H ;

Jekle, A ;

Riehle, A ;

Schwarz, H ;

Berger, J ;

Sandhoff, K ;

Kolesnick, R ;

Gulbins, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) :20589-20596

[48] CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis [J].

Grullich, C ;

Sullards, MC ;

Fuks, Z ;

Merrill, AH ;

Kolesnick, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :8650-8656

[49] Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry [J].

Gu, M ;

Kerwin, JL ;

Watts, JD ;

Aebersold, R .

ANALYTICAL BIOCHEMISTRY, 1997, 244 (02) :347-356

[50] Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide [J].

Gudz, TI ;

Tserng, KY ;

Hoppel, CL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) :24154-24158

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