Evaluation of insulin sensitivity with a new lipid-based index in non-diabetic postmenopausal overweight and obese women before and after a weight loss intervention

被引：16

作者：

Antuna-Puente, Barbara ^{[2
,3
]}

Disse, Emmanuel ^{[4
]}

Faraj, May ^{[1
,5
]}

Lavoie, Marie-Eve ^{[5
]}

Laville, Martine ^{[4
]}

Rabasa-Lhoret, Remi ^{[1
,6
]}

Bastard, Jean-Philippe ^{[2
,3
,7
]}

机构：

[1] Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

[2] Equipe 7, INSERM, CDR 893, F-75012 Paris, France

[3] Univ Paris 06, Fac Med, UMRS680, F-75005 Paris, France

[4] Univ Lyon 1, Hosp Civils Lyon, Ctr Rech Nutr Humaine Rhone Alpes, F-69365 Lyon, France

[5] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada

[6] Ctr Hosp Univ Montreal, Ctr Rech, MDRC, Montreal, PQ, Canada

[7] Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75020 Paris, France

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2009年 / 161卷 / 01期

关键词：

BODY-FAT DISTRIBUTION; CHECK INDEX; GLUCOSE-TOLERANCE; VISCERAL OBESITY; BETA-CELL; RESISTANCE; HEALTHY; QUICKI; CLAMP; INFLAMMATION;

D O I：

10.1530/EJE-09-0091

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To evaluate the Validity of a new lipid-based index (Disse index) in assessing insulin sensitivity (IS) compared with the hyperinsulinemic-euglycemic (HIEG) clamp in overweight and obese. nondiabetic, postmenopausal women, before and after a weight loss intervention. Research design and methods: Association between Disse index and the HIEG clamp Was evaluated in 86 non-diabetic postmenopausal overweight and obese women before and after weight loss. Percentage changes (%Delta) were calculated for several Fasting indices and compared with %Delta of HIEG clamp. Results: We observed a strong correlation between Disse index and HIEG clamp (r = 0.69. P < 0.001). This association was higher than those of homeostasis model assessment (HOMA). quantitative insulin sensitivity check index (QUICKI). and McAuley indices while no significant. difference was observed with Revised-QUICKI. Percent change of Disse index (pre- versus post-weight loss program) was significantly correlated with %Delta of HIEG clamp (r = 0.34, P < 0.01). This correlation was similar to those observed for the other indices tested. Conclusions: We validated the reliability of Disse index in assessing IS in non-diabetic post-menopausal overweight and obese women. before and after weight loss intervention. Disse index may be Useful not only for insulin resistant, diagnostics in this type of population, but. also for the IS follow-up after it weight-loss program and weight stabilization. The presence of lipid elements in this fasting index improves the estimation of IS in overweight and obese non-diabetic post-menopausal women and could add more information about peripheral IS.

引用

页码：51 / 56

页数：6