Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity

被引：603

作者：

Paul, Lynn K.

Brown, Warren S.

Adolphs, Ralph

Tyszka, J. Michael

Richards, Linda J.

Mukherjee, Pratik

Sherr, Elliott H.

机构：

[1] CALTECH, Pasadena, CA 91125 USA

[2] Travis Res Inst, Pasadena, CA 91101 USA

[3] Univ Queensland, Dept Anat & Dev Biol, St Lucia, Qld 4072, Australia

[4] Univ Calif Santa Barbara, Dept Neurol, Santa Barbara, CA 93106 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 04期

关键词：

POTENTIAL INTERHEMISPHERIC TRANSMISSION; MOWAT-WILSON-SYNDROME; BRAIN-DEVELOPMENT; CELL-ADHESION; WHITE-MATTER; HEMISPHERIC-SPECIALIZATION; LANGUAGE REPRESENTATION; SENTENCE COMPREHENSION; DISCONNECTION SYNDROME; ABNORMAL-DEVELOPMENT;

D O I：

10.1038/nrn2107

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1: 4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.

引用

页码：287 / 299

页数：13

共 152 条

[81] ABSENCE OF DISCONNECTION SYNDROME IN CALLOSAL AGENESIS AND EARLY CALLOSOTOMY - BRAIN REORGANIZATION OR LACK OF STRUCTURAL SPECIFICITY DURING ONTOGENY [J].