Angiogenesis in Regenerative Dentistry: Are We Far Enough for Therapy?

被引：29

作者：

Baru, Oana ^{[1
,2
,3
]}

Nutu, Andreea ^{[2
]}

Braicu, Cornelia ^{[2
]}

Cismaru, Cosmin Andrei ^{[2
]}

Berindan-Neagoe, Ioana ^{[2
]}

Buduru, Smaranda ^{[3
,4
]}

Badea, Mindra ^{[5
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Fac Med Dent, Dept Prevent Dent, Cluj Napoca 400083, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400015, Romania

[3] Stomestet Stomatol Clin, Calea Manastur 68A St, Cluj Napoca 400658, Romania

[4] Iuliu Hatieganu Univ Med & Pharm, Prosthet & Dent Mat, Fac Med Dent, 32 Clin St, Cluj Napoca 400006, Romania

[5] Iuliu Hatieganu Univ Med & Pharm, Dept Prevent Dent, Avram Iancu 31, Cluj Napoca 400083, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 02期

关键词：

angiogenesis; mesenchymal stem cells; dental stem cells; tissue regeneration; dental implants;

D O I：

10.3390/ijms22020929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Angiogenesis is a broad spread term of high interest in regenerative medicine and tissue engineering including the dental field. In the last two decades, researchers worldwide struggled to find the best ways to accelerate healing, stimulate soft, and hard tissue remodeling. Stem cells, growth factors, pathways, signals, receptors, genetics are just a few words that describe this area in medicine. Dental implants, bone and soft tissue regeneration using autologous grafts, or xenografts, allografts, their integration and acceptance rely on their material properties. However, the host response, through its vascularization, plays a significant role. The present paper aims to analyze and organize the latest information about the available dental stem cells, the types of growth factors with pro-angiogenic effect and the possible therapeutic effect of enhanced angiogenesis in regenerative dentistry.

引用

页码：1 / 19

页数：19

共 138 条

[1]

VEGF Upregulation in Viral Infections and Its Possible Therapeutic Implications [J].

Alkharsah, Khaled R. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (06)

[2]

Ardeshirylajimi A, 2014, CELL J, V16, P235

[3]

Augello A, 2010, EUR CELLS MATER, V20, P121

[4]

An update on human periapical cyst-mesenchymal stem cells and their potential applications in regenerative medicine [J].

Ayoub, Sara ;

Berberi, Antoine ;

Fayyad-kazan, Mohammad .

MOLECULAR BIOLOGY REPORTS, 2020, 47 (03) :2381-2389

[5]

Comparative analysis of in vitro osteo/odontogenic differentiation potential of human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAP) [J].

Bakopoulou, A. ;

Leyhausen, G. ;

Yolk, J. ;

Tsiftsoglou, A. ;

Garefis, P. ;

Koidis, P. ;

Geurtsen, W. .

ARCHIVES OF ORAL BIOLOGY, 2011, 56 (07) :709-721

[6]

Angiogenic Potential and Secretome of Human Apical Papilla Mesenchymal Stem Cells in Various Stress Microenvironments [J].

Bakopoulou, Athina ;

Kritis, Aristeidis ;

Andreadis, Dimitrios ;

Papachristou, Eleni ;

Leyhausen, Gabriele ;

Koidis, Petros ;

Geurtsen, Werner ;

Tsiftsoglou, Asterios .

STEM CELLS AND DEVELOPMENT, 2015, 24 (21) :2496-2512

[7]

Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology [J].

Bartold, PM ;

McCulloch, CAG ;

Narayanan, AS ;

Pitaru, S .

PERIODONTOLOGY 2000, 2000, 24 :253-269

[8]

Stem Cells [J].

Behr, Bjorn ;

Ko, Sae Hee ;

Wong, Victor W. ;

Gurtner, Geoffrey C. ;

Longaker, Michael T. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2010, 126 (04) :1163-1171

[9]

Berebichez-Fridman Roberto, 2018, Sultan Qaboos Univ Med J, V18, pe264, DOI 10.18295/squmj.2018.18.03.002

[10]

Osteoblasts Derived from Induced Pluripotent Stem Cells Form Calcified Structures in Scaffolds Both in Vitro and in Vivo [J].

Bilousova, Ganna ;

Jun, Du Hyun ;

King, Karen B. ;

De Langhe, Stijn ;

Chick, Wallace S. ;

Torchia, Enrique C. ;

Chow, Kelsey S. ;

Klemm, Dwight J. ;

Roop, Dennis R. ;

Majka, Susan M. .

STEM CELLS, 2011, 29 (02) :206-216

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