Sugar-free Antibodies-The Bacterial Solution to Autoimmunity?

被引：26

作者：

Allhorn, Maria ^{[1
]}

Collin, Mattias ^{[1
]}

机构：

[1] Lund Univ, Div Infect Med, Dept Clin Sci, Biomed Ctr B14, SE-22184 Lund, Sweden

来源：

CONTEMPORARY CHALLENGES IN AUTOIMMUNITY | 2009年 / 1173卷

关键词：

endoglycosidase; immunoglobulin; glycosylation; autoimmunity; autoantibodies; Streptococcus pyogenes; glycan hydrolysis; IGG GLYCAN HYDROLYSIS; STREPTOCOCCUS-PYOGENES; IMMUNOGLOBULIN-G; THERAPEUTIC CLEAVAGE; MURINE LUPUS; ENDOS; ENDOGLYCOSIDASE; AUTOANTIBODIES; GLYCOSYLATION; PROTEIN;

D O I：

10.1111/j.1749-6632.2009.04739.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The enzyme EndoS from Streptococcus pyogenes is an immunomodulatory molecule hydrolyzing the conserved glycans in the effector part of immunoglobulin G (IgG). EndoS is remarkably specific for IgG, and hydrolysis has profound effects on IgG effector functions. EndoS pretreatment of IgG, or direct administration to animals with experimental antibody-mediated autoimmune diseases, inhibits development of disease or cures animals from established disease. The properties of EndoS make it a unique experimental tool and an attractive alternative to current therapies of conditions involving pathogenic antibodies. This review describes the discovery of EndoS, the effects of EndoS on IgG effector functions in vitro and in vivo, the biotechnological potential of EndoS, and the outcomes of EndoS treatment in animal models of autoimmunity.

引用

页码：664 / 669

页数：6

共 29 条

[1] In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner [J].

Albert, Heike ;

Collin, Mattias ;

Dudziak, Diana ;

Ravetch, Jeffrey V. ;

Nimmerjahn, Falk .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (39) :15005-15009

[2] Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis [J].

Allhorn, Maria ;

Olin, Anders I. ;

Nimmerjahn, Falk ;

Collin, Mattias .

PLOS ONE, 2008, 3 (01)

[3] EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity [J].

Allhorn, Maria ;

Olsen, Arne ;

Collin, Mattias .

BMC MICROBIOLOGY, 2008, 8 (1)

[4] SPONTANEOUS MURINE LUPUS-LIKE SYNDROMES - CLINICAL AND IMMUNOPATHOLOGICAL MANIFESTATIONS IN SEVERAL STRAINS [J].

ANDREWS, BS ;

EISENBERG, RA ;

THEOFILOPOULOS, AN ;

IZUI, S ;

WILSON, CB ;

MCCONAHEY, PJ ;

MURPHY, ED ;

ROTHS, JB ;

DIXON, FJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 148 (05) :1198-1215

[5] The impact of glycosylation on the biological function and structure of human immunoglobulins [J].

Arnold, James N. ;

Wormald, Mark R. ;

Sim, Robert B. ;

Rudd, Pauline M. ;

Dwek, Raymond A. .

ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :21-50

[6] Immunology - Sugar determines antibody activity [J].

Burton, Dennis R. ;

Dwek, Raymond A. .

SCIENCE, 2006, 313 (5787) :627-628

[7] IMMUNOGLOBULIN-G - FUNCTIONAL SITES [J].

BURTON, DR .

MOLECULAR IMMUNOLOGY, 1985, 22 (03) :161-206

[8] CLONING AND EXPRESSION OF THE BETA-N-ACETYLGLUCOSAMINIDASE GENE FROM STREPTOCOCCUS-PNEUMONIAE - GENERATION OF TRUNCATED ENZYMES WITH MODIFIED AGLYCON SPECIFICITY [J].

CLARKE, VA ;

PLATT, N ;

BUTTERS, TD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (15) :8805-8814

[9] A novel secreted endoglycosidase from Enterococcus faecalis with activity on human immunoglobulin G and ribonuclease B [J].

Collin, M ;

Fischetti, VA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (21) :22558-22570

[10] Extracellular enzymes with immunomodulating activities:: Variations on a theme in Streptococcus pyogenes [J].

Collin, M ;

Olsén, A .

INFECTION AND IMMUNITY, 2003, 71 (06) :2983-2992

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