Indolocarbazole natural products:: occurrence, biosynthesis, and biological activity

被引：370

作者：

Sanchez, Cesar

Mendez, Carmen

Salas, Jose A. ^{[1
]}

机构：

[1] Univ Oviedo, Dept Biol Func, E-33006 Oviedo, Spain

[2] Univ Oviedo, IUOPA, E-33006 Oviedo, Spain

来源：

NATURAL PRODUCT REPORTS | 2006年 / 23卷 / 06期

关键词：

D O I：

10.1039/b601930g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The indolocarbazole family of natural products, including the biosynthetically related bisindolylmaleimides, is reviewed ( with 316 references cited). The isolation of indolocarbazoles from natural sources and the biosynthesis of this class of compounds are thoroughly reviewed, including recent developments in molecular genetics, enzymology and metabolic engineering. The biological activities and underlying modes of action displayed by natural and synthetic indolocarbazoles is also presented, with an emphasis on the development of analogs that have entered clinical trials for its future use against cancer or other diseases.

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页码：1007 / 1045

页数：39

相关论文

共 315 条

[1] Inhibition of PKC β by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients [J].

Aiello, LP ;

Clermont, A ;

Arora, V ;

Davis, MD ;

Sheetz, MJ ;

Bursell, SE .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (01) :86-92

[2] Practical synthesis of a potent indolocarbazole-based, DNA topoisomerase inhibitor [J].

Akao, A ;

Hiraga, S ;

Iida, T ;

Kamatani, A ;

Kawasaki, M ;

Mase, T ;

Nemoto, T ;

Satake, N ;

Weissman, SA ;

Tschaen, DM ;

Rossen, K ;

Petrillo, D ;

Reamer, RA ;

Volante, RP .

TETRAHEDRON, 2001, 57 (43) :8917-8923

[3]

Akinaga S, 2000, ANTI-CANCER DRUG DES, V15, P43

[4] Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors [J].

Al-awar, RS ;

Ray, JE ;

Hecker, KA ;

Joseph, S ;

Huang, JP ;

Shih, C ;

Brooks, HB ;

Spencer, CD ;

Watkins, SC ;

Schultz, RM ;

Considine, EL ;

Faul, MM ;

Sullivan, KA ;

Kolis, SP ;

Carr, MA ;

Zhang, FM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (15) :3925-3928

[5] The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1 beta (Rsk-2) and p70 S6 kinase [J].

Alessi, DR .

FEBS LETTERS, 1997, 402 (2-3) :121-123

[6] Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety [J].

Anizon, F ;

Moreau, P ;

Sancelme, M ;

Laine, W ;

Bailly, C ;

Prudhomme, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (17) :3709-3722

[7] Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin [J].

Anizon, F ;

Moreau, P ;

Sancelme, M ;

Voldoire, A ;

Prudhomme, M ;

Ollier, M ;

Severe, D ;

Riou, JF ;

Bailly, C ;

Fabbro, D ;

Meyer, T ;

Aubertin, AM .

BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (09) :1597-1604

[8]

[Anonymous], 1993, STUDIES NATURAL PROD

[9]

[Anonymous], 1987, PROG CHEM ORG NAT PR

[10]

ARAKAWA H, 1995, CANCER RES, V55, P1316

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