Towards patient-specific tumor antigen selection for vaccination

被引：54

作者：

Rammensee, HG ^{[1
]}

Weinschenk, T ^{[1
]}

Gouttefangeas, C ^{[1
]}

Stevanovic, S ^{[1
]}

机构：

[1] Univ Tubingen, Inst Cell Biol, Dept Immunol, D-72076 Tubingen, Germany

来源：

IMMUNOLOGICAL REVIEWS | 2002年 / 188卷

关键词：

D O I：

10.1034/j.1600-065X.2002.18815.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, we discuss the possibilities for combining the power of molecular analysis of the antigens expressed in a given individual tumor with the design of a tailored vaccine containing defined antigens. Step 1 is a differential gene expression analysis of tumor and corresponding normal tissue. Step 2 is the analysis of human leukocyte antigen (HLA) ligands on tumor cells. Step 3 is data mining with the aim to select those antigens that might be suitable for tumor attack by the adaptive immune system. Step 4 is the on-the-spot clinical grade production of the constituents of the patient tailored vaccine, e.g. peptides. Step 5 is then vaccination and monitoring. Although it will not be possible to cover all relevant antigens expressed in a tumor, the antigens that can be identified with our present technical possibilities might be enough for improved immunotherapy. The scope of the present review is to explore the possibilities and the formidable technical and logistical challenge for such individual patient-oriented antigen definition to be used for therapeutic immunization.

引用

页码：164 / 176

页数：13

共 137 条

[91] The major substrates for TAP in vivo are derived from newly synthesized proteins [J].

Reits, EAJ ;

Vos, JC ;

Grommé, M ;

Neefjes, J .

NATURE, 2000, 404 (6779) :774-778

[92] A listing of human tumor antigens recognized by T cells [J].

Renkvist, N ;

Castelli, C ;

Robbins, PF ;

Parmiani, G .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2001, 50 (01) :3-15

[93]

Renner C, 2001, ANN HEMATOL, V80, P255

[94] Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes [J].

Romero, P ;

Dunbar, PR ;

Valmori, D ;

Pittet, M ;

Ogg, GS ;

Rimoldi, D ;

Chen, JL ;

Liénard, D ;

Cerottini, JC ;

Cerundolo, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (09) :1641-1650

[95] Progress in human tumour immunology and immunotherapy [J].

Rosenberg, SA .

NATURE, 2001, 411 (6835) :380-384

[96]

Rosty C, 2002, CANCER RES, V62, P1868

[97] Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer [J].

Saeterdal, I ;

Bjorheim, J ;

Lislerud, K ;

Gjertsen, MK ;

Bukholm, IK ;

Olsen, OC ;

Nesland, JM ;

Eriksen, JA ;

Moller, M ;

Lindblom, A ;

Gaudernack, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (23) :13255-13260

[98] HUMAN NEOPLASMS ELICIT MULTIPLE SPECIFIC IMMUNE-RESPONSES IN THE AUTOLOGOUS HOST [J].

SAHIN, U ;

TURECI, O ;

SCHMITT, H ;

COCHLOVIUS, B ;

JOHANNES, T ;

SCHMITS, R ;

STENNER, F ;

LUO, GR ;

SCHOBERT, I ;

PFREUNDSCHUH, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11810-11813

[99] Identification of cancer/testis genes by database mining and mRNA expression analysis [J].

Scanlan, MJ ;

Gordon, CM ;

Williamson, B ;

Lee, SY ;

Chen, YT ;

Stockert, E ;

Jungbluth, A ;

Ritter, G ;

Jäger, D ;

Jäger, E ;

Knuth, A ;

Old, LJ .

INTERNATIONAL JOURNAL OF CANCER, 2002, 98 (04) :485-492

[100] Quantitation of antigen-reactive T cells in peripheral blood by IFNγ-ELISPOT assay and chromium-release assay:: a four-centre comparative trial [J].

Scheibenbogen, C ;

Romero, P ;

Rivoltini, L ;

Herr, W ;

Schmittel, A ;

Cerottini, JC ;

Woelfel, T ;

Eggermont, AMM ;

Keilholz, U .

JOURNAL OF IMMUNOLOGICAL METHODS, 2000, 244 (1-2) :81-89

← 5 6 7 8 9 10 11 12 13 14 →