A new anticoagulant-antidote pair: Control of thrombin activity by aptamers and porphyrins

被引：48

作者：

Joachimi, Astrid

Mayer, Guenter

Hartig, Joerg S.

机构：

[1] Univ Konstanz, Dept Chem, D-78457 Constance, Germany

[2] Univ Bonn, LIMES, D-53121 Bonn, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 11期

关键词：

D O I：

10.1021/ja0677822

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cationic porphyrins have been described to bind to G-quadruplexes with high affinities. In combination with G-quadruplex containing DNA aptamers that bind and inhibit the blood clotting factor thrombin, these molecules act as true antidotes that revert the anticoagulant activity of the aptamer. Porphyrins in concert with four-stranded aptamers therefore represent a novel anticoagulant/antidote class within the blood clotting cascade.

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页码：3036 / +

页数：3

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