An anticoagulant with light-triggered antidote activity

被引：51

作者：

Heckel, Alexander

Buff, Maximilian C. R.

Raddatz, Marie-Sophie L.

Mueller, Jens

Poetzsch, Bernd

Mayer, Guenter

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, Program Unit Chem Biol & Med Chem, LIMES, D-53121 Bonn, Germany

[2] Univ Hosp Bonn, Inst Expt Hematol & Transfus Med, D-53105 Bonn, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 40期

关键词：

antisense agents; aptamers; blood clotting; caged compounds; DNA;

D O I：

10.1002/anie.200602346

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A light remedy to overdosing: Aptamers with an intramolecular "caged" antisense region remain active until they are irradiated. Upon irradiation, the antisense activity is released and the aptamer refolds into an inactive structure (see scheme). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6748 / 6750

页数：3

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