Photoinduced transcription by using temporarily mismatched caged oligonucleotides

被引：112

作者：

Kröck, L ^{[1
]}

Heckel, A ^{[1
]}

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 03期

关键词：

DNA; gene expression; oligonucleotides; photoactivation;

D O I：

10.1002/anie.200461779

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Spatial and temporal control of the function of DNA with light: In oligonucleotides, protected ("caged") thymidine can act as a temporary mismatch in base pairing and, for example, prevent transcription. The photolabile caging group can be removed by light (see picture), fully restoring an intact DNA strand. (Chemical Equation Presented).

引用

页码：471 / 473

页数：3

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