Light-induced formation of G-quadruplex DNA secondary structures

被引：60

作者：

Mayer, G ^{[1
]}

Kröck, L ^{[1
]}

Mikat, V ^{[1
]}

Engeser, M ^{[1
]}

Heckel, A ^{[1
]}

机构：

[1] Univ Bonn, Inst Organ Chem & Biochem, D-53121 Bonn, Germany

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 11期

关键词：

D O I：

10.1002/cbic.200500198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A little light release: Temporarily blocked ("caged") dG nucleosides that can be incorporated into oligodeoxynucleotides are presented (see figure). Their hydrogen-bond-recognition site is inaccessible in the inactive form; this prevents, for example, the formation of secondary structures. Light can trigger the release of the unmodified oligonucleotide and thus induce correct folding. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1966 / 1970

页数：5

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