Light-induced formation of G-quadruplex DNA secondary structures

被引：60

作者：

Mayer, G ^{[1
]}

Kröck, L ^{[1
]}

Mikat, V ^{[1
]}

Engeser, M ^{[1
]}

Heckel, A ^{[1
]}

机构：

[1] Univ Bonn, Inst Organ Chem & Biochem, D-53121 Bonn, Germany

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 11期

关键词：

D O I：

10.1002/cbic.200500198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A little light release: Temporarily blocked ("caged") dG nucleosides that can be incorporated into oligodeoxynucleotides are presented (see figure). Their hydrogen-bond-recognition site is inaccessible in the inactive form; this prevents, for example, the formation of secondary structures. Light can trigger the release of the unmodified oligonucleotide and thus induce correct folding. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1966 / 1970

页数：5

共 33 条

[11] Light regulation of aptamer activity: An anti-thrombin aptamer with caged thymidine nucleobases [J].

Heckel, A ;

Mayer, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (03) :822-823

[12] G-quartet oligonucleotides: A new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis [J].

Jing, NJ ;

Li, YD ;

Xiong, WJ ;

Sha, W ;

Jing, L ;

Tweardy, DJ .

CANCER RESEARCH, 2004, 64 (18) :6603-6609

[13] Photoinduced transcription by using temporarily mismatched caged oligonucleotides [J].

Kröck, L ;

Heckel, A .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (03) :471-473

[14]

Krock L., 2005, ANGEW CHEM, V117, P475

[15] Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform [J].

Ladame, S ;

Schouten, JA ;

Stuart, J ;

Roldan, J ;

Neidle, S ;

Balasubramanian, S .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (20) :2925-2931

[16] A NOVEL NUCLEOTIDE-BASED THROMBIN INHIBITOR INHIBITS CLOT-BOUND THROMBIN AND REDUCES ARTERIAL PLATELET THROMBUS FORMATION [J].

LI, WX ;

KAPLAN, AV ;

GRANT, GW ;

TOOLE, JJ ;

LEUNG, LLK .

BLOOD, 1994, 83 (03) :677-682

[17] Interaction of human nuclear topoisomerase I with guanosine quartet-forming and guanosine-rich single-stranded DNA and RNA oligonucleotides [J].

Marchand, C ;

Pourquier, P ;

Laco, GS ;

Jing, NJ ;

Pommier, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) :8906-8911

[18]

MARIOTT G, 1998, METHODS ENZYMOLOGY, V291

[19] Inhibition of the human immunodeficiency virus type I integrase by guanosine quartet structures [J].

Mazumder, A ;

Neamati, N ;

Ojwang, JO ;

Sunder, S ;

Rando, RF ;

Pommier, Y .

BIOCHEMISTRY, 1996, 35 (43) :13762-13771

[20] Natural and pharmacological regulation of telomerase [J].

Mergny, JL ;

Riou, JF ;

Mailliet, P ;

Teulade-Fichou, MP ;

Gilson, E .

NUCLEIC ACIDS RESEARCH, 2002, 30 (04) :839-865

← 1 2 3 4 →