TOPAL 2.0: improved detection of mosaic sequences within multiple alignments

被引：111

作者：

McGuire, G

Wright, F ^{[1
]}

机构：

[1] Scottish Crop Res Inst, Dundee DD2 5DA, Scotland

[2] Isaac Newton Inst Math Sci, Cambridge CB3 0EH, England

来源：

BIOINFORMATICS | 2000年 / 16卷 / 02期

关键词：

D O I：

10.1093/bioinformatics/16.2.130

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: The Dss statistic Mms proposed by McGuire et al. (Mol. Biol. Evol., 14, 1125-1131, 1997) for scanning data sets for the presence of recombination, an important step in some phylogenetic analyses. The statistic, however; could not distinguish well between among-site rate variation and recombination, and had no statistical test for significant values. This paper addresses these shortfalls. Results: A modification to the Dss statistic is proposed which accounts for rate variation to a large extent. A statistical test, based on parametric bootstrapping, is also suggested.

引用

页码：130 / 134

页数：5

共 23 条

[11]

LAWRENCE JG, 1992, GENETICS, V131, P753

[12] TOPAL: recombination detection in DNA and protein sequences [J].