Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3

被引：17

作者：

Kiss, H

Darai, E

Kiss, C

Kost-Alimova, M

Klein, G

Dumanski, JP

Imreh, S

机构：

[1] Karolinska Inst, Ctr Microbiol & Tumor Biol, MTC, S-17117 Stockholm, Sweden

[2] Univ Uppsala Hosp, Dept Genet & Pathol, Rudbeck Lab, S-75185 Uppsala, Sweden

来源：

MAMMALIAN GENOME | 2002年 / 13卷 / 11期

关键词：

D O I：

10.1007/s00335-002-3037-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interspecies sequence comparison offers an effective approach to identify conserved elements that might have functional importance. We compared 1.32 Mb of C3CER1 (referred also as CER1) from human Chromosome (Chr) 3p21.3 to its orthologous regions on mouse Chr 9F. The corresponding mouse region was found divided into two blocks, but their gene content and gene positions were highly conserved between human and mouse. We observed that two orthologous mouse genes (Xtrp3s1 and Cmkbr1) were duplicated, and this resulted in two additional expressed mouse genes (Xtrp3 and Cmkbr111). We also recognized a large number of conserved elements that were neither exons, CpG islands, nor repeats. We further identified and characterized five novel orthologous mouse genes (Kiaa0028, Xtrp3sl, Fycol, Tmem17, and Lrrc2).

引用

页码：646 / 655

页数：10

共 32 条

[1] Confirmation of the mapping of a 12-O-tetradecanoylphorbol-13-acetate promotion susceptibility locus, Psl1, to distal mouse chromsome 9 [J].