Pressure diuresis and natriuresis in DOCA-salt mice

被引：26

作者：

Gross, V

Lippoldt, A

Luft, FC

机构：

[1] HUMBOLDT UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,FRANZ VOLHARD CLIN,D-13122 BERLIN,GERMANY

[2] HUMBOLDT UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,MAX DELBRUCK CTR MOL MED,D-13122 BERLIN,GERMANY

来源：

KIDNEY INTERNATIONAL | 1997年 / 52卷 / 05期

关键词：

pressure natriuresis; pressure diuresis; renal blood flow; hypertension; salt sensitivity; mouse physiology;

D O I：

10.1038/ki.1997.462

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The increasing use of mice in renal and cardiovascular studies has necessitated adapting physiological methods used for rats to mice, which are far smaller in size. We have adapted measurements of continuous renal blood flow, pressure natriuresis and diuresis, and laser-Doppler cortical and medullary flow to 40 g mice with DOCA-salt hypertension. We demonstrated a rightward shift in the pressure natriuresis-diuresis curve. We conclude that with current, commercially-available equipment, sophisticated renal physiology can be conducted in the mouse. These methods will be important to investigations of gene-targeted mice.

引用

页码：1364 / 1368

页数：5