A multifunctional polymeric coating incorporating lawsone with corrosion resistance and antibacterial activity for biomedical Mg alloys

被引：58

作者：

Asadi, Hamid ^{[1
]}

Suganthan, Baviththira ^{[1
]}

Ghalei, Sama ^{[1
]}

Handa, Hitesh ^{[1
]}

Ramasamy, Ramaraja P. ^{[1
]}

机构：

[1] Univ Georgia, Sch Chem Mat & Biomed Engn, Athens, GA 30602 USA

来源：

PROGRESS IN ORGANIC COATINGS | 2021年 / 153卷

关键词：

Biodegradable magnesium implants; Lawsonia inermis (Henna); Polymeric coating; AZ31; alloy; Polycaprolactone (PCL); Antibacterial activity; Corrosion protection;

D O I：

10.1016/j.porgcoat.2021.106157

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The clinical application of magnesium (Mg)-based alloys as temporary orthopedic implants is highly limited by their rapid corrosion rate in the physiological environment. Herein, an anti-corrosive polymeric coating based on polycaprolactone (PCL) and lawsone was prepared on AZ31 Mg alloy to improve its corrosion resistance. Lawsone was incorporated into the coating as a corrosion inhibitor to enhance the passive corrosion protection of the PCL coating through its strong chelation ability of dissolving Mg2+. Anti-corrosion properties of the coatings were assessed by electrochemical techniques and in vitro immersion tests, and the results demonstrated a remarkable improvement in corrosion resistance of the bare Mg alloy. In addition to the corrosion inhibition effect, incorporation of lawsone provided the coating with a strong antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains. Moreover, the fabricated coating was cytocompatible (viability of > 85 %) toward human fetal osteoblast cells. The findings of this work highlighted the great potential of lawsone as a natural corrosion inhibitor for fabrication of corrosion protective, antibacterial, and biocompatible coatings on Mg-based biodegradable implants.

引用

页数：14

共 92 条

[31]

Biocompatibility, corrosion resistance and antibacterial activity of TiO2/CuO coating on titanium [J].