Heme oxygenase-1 - A novel drug target for atherosclerotic diseases?

被引:197
作者
Stocker, Roland [1 ]
Perrella, Mark A.
机构
[1] Univ New S Wales, Fac Med, Sch Med Sci, Ctr Vasc Res, Sydney, NSW, Australia
[2] Prince Wales Hosp, Dept Haematol, Sydney, NSW, Australia
[3] Brigham & Womens Hosp, Div Pulm & Crit Care, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
关键词
atherosclerosis; cardiovascular diseases; endothelium; inflammation; metabolism; pharmacology; vasodilation;
D O I
10.1161/CIRCULATIONAHA.105.598698
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2178 / 2189
页数:12
相关论文
共 120 条
[71]   A precursor of the nitric oxide donor SIN-1 modulates the stress protein heme oxygenase-1 in rat liver [J].
Motterlini, R ;
Hidalgo, A ;
Sammut, I ;
Shah, KA ;
Mohammed, S ;
Srai, K ;
Green, CJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 225 (01) :167-172
[72]   NO-mediated activation of heme oxygenase: Endogenous cytoprotection against oxidative stress to endothelium [J].
Motterlini, R ;
Foresti, R ;
Intaglietta, M ;
Winslow, RM .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 270 (01) :H107-H114
[73]   Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury [J].
Nakao, A ;
Murase, N ;
Ho, C ;
Toyokawa, H ;
Billiar, TR ;
Kanno, S .
CIRCULATION, 2005, 112 (04) :587-591
[74]   Tumor necrosis factor-α-induced iron sequestration and oxidative stress in human endothelial cells [J].
Nanami, M ;
Ookawara, T ;
Otaki, Y ;
Ito, K ;
Moriguchi, R ;
Miyagawa, K ;
Hasuike, Y ;
Izumi, M ;
Eguchi, H ;
Suzuki, K ;
Nakanishi, T .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (12) :2495-2501
[75]   Regulatory mechanisms controlling gene expression mediated by the antioxidant response element [J].
Nguyen, T ;
Sherratt, PJ ;
Pickett, CB .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2003, 43 :233-260
[76]   Bilirubin -: A natural inhibitor of vascular smooth muscle cell proliferation [J].
Öllinger, R ;
Bilban, M ;
Erat, A ;
Froio, A ;
McDaid, J ;
Tyagi, S ;
Csizmadia, E ;
Graça-Souza, AV ;
Liloia, A ;
Soares, MP ;
Otterbein, LE ;
Usheva, A ;
Yamashita, K ;
Bach, FH .
CIRCULATION, 2005, 112 (07) :1030-1038
[77]   Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury [J].
Omura, S ;
Suzuki, H ;
Toyofuku, M ;
Ozono, R ;
Kohno, N ;
Igarashi, K .
GENES TO CELLS, 2005, 10 (03) :277-285
[78]   A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese [J].
Ono, K ;
Goto, Y ;
Takagi, S ;
Baba, S ;
Tago, N ;
Nonogi, H ;
Iwai, N .
ATHEROSCLEROSIS, 2004, 173 (02) :315-319
[79]   Heme oxygenase-1: unleashing the protective properties of heme [J].
Otterbein, LE ;
Soares, MP ;
Yamashita, K ;
Bach, FH .
TRENDS IN IMMUNOLOGY, 2003, 24 (08) :449-455
[80]   Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway [J].
Otterbein, LE ;
Bach, FH ;
Alam, J ;
Soares, M ;
Lu, HT ;
Wysk, M ;
Davis, RJ ;
Flavell, RA ;
Choi, AMK .
NATURE MEDICINE, 2000, 6 (04) :422-428