In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus

Oral ENA713 (0.5, 1.5 and 4.5 mg/kg), an acetylcholinesterase inhibitor (AChEI), dose-dependently enhanced extracellular acetylcholine concentrations in the hippocampus of freely moving rats. This effect was paralleled by changes in both noradrenergic and dopaminergic transmission. In particular, ENA713 significantly decreased noradrenaline concentrations, whereas it significantly increased homovanillic acid levels, without affecting dopamine concentrations. Neither serotonin nor gamma-aminobutyric acid levels were modified by ENA713. These findings extend the neurochemical profile of ENA713 and suggest that it could be useful fur the treatment of Alzheimer-type dementia which is associated with multiple neurotransmitter abnormalities in the brain. (C) 2000 Elsevier Science B.V. All rights reserved.