Intracellular hyperthermia for cancer using magnetite cationic liposomes: Ex vivo study

被引：53

作者：

Yanase, M

Shinkai, M

Honda, H

Wakabayashi, T

Yoshida, J

Kobayashi, T

机构：

[1] NAGOYA UNIV, DEPT BIOTECHNOL, GRAD SCH ENGN, CHIKUSA KU, NAGOYA, AICHI 46401, JAPAN

[2] NAGOYA UNIV, SCH MED, DEPT NEUROSURG, SHOWA KU, NAGOYA, AICHI 466, JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1997年 / 88卷 / 07期

关键词：

cationic liposome; magnetite; magnetoliposome; intracellular hyperthermia; glioma cell;

D O I：

10.1111/j.1349-7006.1997.tb00429.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heating properties of magnetite cationic liposomes (MCL) were investigated in ex vivo experiments using implanted cell pellets. The cell pellets, which consisted of rat glioma T9 cells into which MCL had been incorporated in a petri dish, were implanted subcutaneously in the left femoral region of female F344 rats. The rats were placed in a magnetic field generating coil and irradiated with an alternating magnetic field (384 Oe, 118 kHz) for 60 min. The cell pellets were heated to over 43 degrees C by MCL in the magnetic field, but other body parts of the rats were not heated. After 3 cycles of magnetic heating, all glioma cells were killed and no tumor take was observed.

引用

页码：630 / 632

页数：3

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