Ceramide in the eukaryotic stress response

被引：654

作者：

Hannun, YA ^{[1
]}

Luberto, C ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29495 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0962-8924(99)01694-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha chemotherapeutic agents and heat cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.

引用

页码：73 / 80

页数：8

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