Clinical importance of the cytochromes P450

被引:1057
作者
Nebert, DW [1 ]
Russell, DW
机构
[1] Univ Cincinnati, Med Ctr, Ctr Environm Genet, Cincinnati, OH 45267 USA
[2] Univ Cincinnati, Med Ctr, Dept Environm Hlth, Cincinnati, OH 45267 USA
[3] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX USA
关键词
D O I
10.1016/S0140-6736(02)11203-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D-3 synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated In important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases.
引用
收藏
页码:1155 / 1162
页数:8
相关论文
共 72 条
  • [41] Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology
    Nebert, DW
    [J]. PHARMACOGENETICS, 2000, 10 (04): : 279 - 290
  • [42] NEBERT DW, 2002, EMERY RIMOINS PRINCI, P590
  • [43] NEBERT DW, ENCY HUMAN GENOME
  • [44] THE P450 SUPERFAMILY - UPDATE ON NEW SEQUENCES, GENE-MAPPING, ACCESSION NUMBERS, EARLY TRIVIAL NAMES OF ENZYMES, AND NOMENCLATURE
    NELSON, DR
    KAMATAKI, T
    WAXMAN, DJ
    GUENGERICH, FP
    ESTABROOK, RW
    FEYEREISEN, R
    GONZALEZ, FJ
    COON, MJ
    GUNSALUS, IC
    GOTOH, O
    OKUDA, K
    NEBERT, DW
    [J]. DNA AND CELL BIOLOGY, 1993, 12 (01) : 1 - 51
  • [45] P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
    Nelson, DR
    Koymans, L
    Kamataki, T
    Stegeman, JJ
    Feyereisen, R
    Waxman, DJ
    Waterman, MR
    Gotoh, O
    Coon, MJ
    Estabrook, RW
    Gunsalus, IC
    Nebert, DW
    [J]. PHARMACOGENETICS, 1996, 6 (01): : 1 - 42
  • [46] NELSON DR, CYTOCHROME P450 GENE
  • [47] Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein
    Norman, AW
    Ishizuka, S
    Okamura, WH
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2001, 76 (1-5) : 49 - 59
  • [48] OSCARSON M, HUMAN CYTOCHROME P45
  • [49] Potential role of pharmacogenomics in reducing adverse drug reactions - A systematic review
    Phillips, KA
    Veenstra, DL
    Oren, E
    Lee, JK
    Sadee, W
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (18): : 2270 - 2279
  • [50] Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde
    Plastaras, JP
    Guengerich, FP
    Nebert, DW
    Marnett, LJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) : 11784 - 11790