Translocations in epithelial cancers

被引：31

作者：

Brenner, J. Chad ^{[1
,2
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1796卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Translocation; Epithelial; Rearrangement; Gene fusion; Chimera; MLL; ERG; ALK; HMGA2; COPA; RENAL-CELL CARCINOMA; BROMODOMAIN PROTEIN BRD4; TMPRSS2-ERG GENE FUSION; ABL TYROSINE KINASE; FOLLICULAR THYROID CARCINOMAS; CHRONIC MYELOID-LEUKEMIA; C-MYC ONCOGENE; PROSTATE-CANCER; EML4-ALK FUSION; TRANSCRIPTION FACTOR;

D O I：

10.1016/j.bbcan.2009.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic translocations leading to the expression of chimeric transcripts characterize several hematologic, mesenchymal and epithelial malignancies. While several gene fusions have been linked to essential molecular events in hematologic malignancies, the identification and characterization of recurrent chimeric transcripts in epithelial cancers has been limited. However, the recent discovery of the recurrent gene fusions in prostate cancer has sparked a revitalization of the quest to identify novel rearrangements in epithelial malignancies. Here, the molecular mechanisms of gene fusions that drive several epithelial cancers and the recent technological advances that increase the speed and reliability of recurrent gene fusion discovery are explored. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：201 / 215

页数：15

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