The neurotrophin receptor p75NTR as a positive modulator of myelination

被引：273

作者：

Cosgaya, JM ^{[1
]}

Chan, JR ^{[1
]}

Shooter, EM ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA

来源：

SCIENCE | 2002年 / 298卷 / 5596期

关键词：

D O I：

10.1126/science.1076595

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Schwann cells in developing and regenerating peripheral nerves express elevated levels of the neurotrophin receptor p75(NTR). Neurotrophins are key mediators of peripheral nervous system myelination. Our results show that myelin formation is inhibited in the absence of functional p75(NTR) and enhanced by blocking TrkC activity. Moreover, the enhancement of myelin formation by endogenous brain-derived neurotrophic factor is mediated by the p75(NTR) receptor, whereas TrkC receptors are responsible for neurotrophin-3 inhibition. Thus p75(NTR) and TrkC receptors have opposite effects on myelination.

引用

页码：1245 / 1248

页数：4

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