A practical, efficient, and rapid method for the oxidation of electron deficient pyridines using trifluoroacetic anhydride and hydrogen peroxide-urea complex

被引：72

作者：

Caron, S ^{[1
]}

Do, NM ^{[1
]}

Sieser, JE ^{[1
]}

机构：

[1] Pfizer Inc, Pfizer Cent Res, Proc Res & Dev, Groton, CT 06340 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

oxidation; pyridines; N-oxides; peroxides;

D O I：

10.1016/S0040-4039(00)00165-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the oxidation of electron-poor pyridines to their N-oxides using UHP and TFAA in either CH2Cl2 or CH3CN was developed. The methodology proved to tolerate a number of functional groups and substitution patterns and proceeded on notoriously difficult to oxidize substrates. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2299 / 2302

页数：4

共 11 条

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[10] Swern D., 1971, In Organic peroxides, V2, P355

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