Surrogate marker of preclinical tuberculosis in human immunodeficiency virus infection: Antibodies to an 88-kDa secreted antigen of Mycobacterium tuberculosis

被引:51
作者
Laal, S
Samanich, KM
Sonnenberg, MG
Belisle, JT
OLeary, J
Simberkoff, MS
ZollaPazner, S
机构
[1] NYU,MED CTR,DEPT PATHOL,NEW YORK,NY 10016
[2] COLORADO STATE UNIV,DEPT MICROBIOL,FT COLLINS,CO 80523
关键词
D O I
10.1086/514015
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antibodies to purified, size-fractionated secreted proteins of Mycobacterium tuberculosis in sera from patients with human immunodeficiency virus (HIV) infection and active tuberculosis (HIV/TB patients), and in stored sera obtained from the same patients prior to clinical manifestation of TB, were evaluated by ELISA, and the repertoire of antigens recognized was analyzed by immunoblotting, Compared with non-HIV/TB patients, HIV/TB patients had lower levels of anti-mycobacterial antibodies, and these were directed toward a restricted set of antigens, Antibodies to an 88-kDa secreted antigen were present in the sera of 74% of HIV/TB patients during the years (1.5-6) prior to manifestation of active, clinical tuberculosis, although only 66% were positive by the time tuberculosis was diagnosed, The presence of antibodies to the 88-kDa antigen can serve as a surrogate marker for identifying HIV-infected persons with active, subclinical disease who are at a high risk of developing clinical tuberculosis.
引用
收藏
页码:133 / 143
页数:11
相关论文
共 44 条
  • [11] AN OUTBREAK OF TUBERCULOSIS WITH ACCELERATED PROGRESSION AMONG PERSONS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS - AN ANALYSIS USING RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS
    DALEY, CL
    SMALL, PM
    SCHECTER, GF
    SCHOOLNIK, GK
    MCADAM, RA
    JACOBS, WR
    HOPEWELL, PC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (04) : 231 - 235
  • [12] DANIEL TM, 1987, AM REV RESPIR DIS, V135, P1137
  • [13] DAS S, 1992, CLIN EXP IMMUNOL, V89, P402
  • [14] THE VARIABLE C-TERMINAL REGION OF THE MYCOBACTERIUM-LEPRAE 70-KILODALTON HEAT-SHOCK PROTEIN IS THE TARGET FOR HUMORAL IMMUNE-RESPONSES
    DAVENPORT, MP
    MCKENZIE, KR
    BASTEN, A
    BRITTON, WJ
    [J]. INFECTION AND IMMUNITY, 1992, 60 (03) : 1170 - 1177
  • [15] DELGIUDICE G, 1993, J IMMUNOL, V150, P2025
  • [16] AN OUTBREAK OF MULTIDRUG-RESISTANT TUBERCULOSIS AMONG HOSPITALIZED-PATIENTS WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME
    EDLIN, BR
    TOKARS, JI
    GRIECO, MH
    CRAWFORD, JT
    WILLIAMS, J
    SORDILLO, EM
    ONG, KR
    KILBURN, JO
    DOOLEY, SW
    CASTRO, KG
    JARVIS, WR
    HOLMBERG, SD
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (23) : 1514 - 1521
  • [17] ESPITIA C, 1989, CLIN EXP IMMUNOL, V77, P373
  • [18] DETECTION OF ANTI-P-32 MYCOBACTERIAL IGG ANTIBODIES IN PATIENTS WITH AIDS
    FARBER, CM
    YERNAULT, JC
    LEGROS, F
    DEBRUYN, J
    VANVOOREN, JP
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (01) : 279 - 280
  • [19] THE IMPACT OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION ON TUBERCULOSIS AND ITS CONTROL
    FITZGERALD, JM
    GRZYBOWSKI, S
    ALLEN, EA
    [J]. CHEST, 1991, 100 (01) : 191 - 200
  • [20] DELAYED-TYPE HYPERSENSITIVITY SKIN-TESTS ARE AN INDEPENDENT PREDICTOR OF HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE PROGRESSION
    GORDIN, FM
    HARTIGAN, PM
    KLIMAS, NG
    ZOLLAPAZNER, SB
    SIMBERKOFF, MS
    HAMILTON, JD
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (04) : 893 - 897