The Catalytic Asymmetric Intramolecular Stetter Reaction

被引：179

作者：

de Alaniz, Javier Read ^{[1
]}

Rovis, Tomislav ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

SYNLETT | 2009年 / 08期

基金：

美国国家卫生研究院;

关键词：

asymmetric synthesis; triazolium salts; quaternary stereocenters; carbene catalysis; nucleophilic catalysis; organocatalysis; Stetter reaction; benzoin reaction; N-HETEROCYCLIC CARBENES; BICYCLIC THIAZOLIUM SALTS; ACYL ANION EQUIVALENTS; BENZOIN CONDENSATION; ENANTIOSELECTIVE SYNTHESIS; QUATERNARY STEREOCENTERS; CONJUGATE ADDITION; NUCLEOPHILIC CARBENES; 2+2+2 CYCLOADDITION; EFFICIENT SYNTHESIS;

D O I：

10.1055/s-0029-1216654

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This Account chronicles our efforts in the development of the catalytic asymmetric Stetter reaction using chiral triazolium salts as small molecule organic catalysts. Advances in the mechanistically related azolium-catalyzed asymmetric benzoin reaction are discussed, particularly as they apply to catalyst design. A chronological treatise of reaction discovery, catalyst optimization and reactivity extension follows.

引用

页码：1189 / 1207

页数：19

共 100 条

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