Non-leaching surfaces capable of killing microorganisms on contact

被引:147
作者
Ferreira, L. [1 ,2 ]
Zumbuehl, A. [3 ]
机构
[1] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal
[2] Biocant Ctr Biotechnol Innovat Ctr, P-3060197 Cantanhede, Portugal
[3] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
关键词
ANTIMICROBIAL ACTIVITY; EXPANDED POLY(TETRAFLUOROETHYLENE); ANTIBACTERIAL SURFACES; BACTERIAL BIOFILMS; GENE-EXPRESSION; POLYMER SURFACE; TITANIUM-ALLOY; US HOSPITALS; TOTAL HIP; CHITOSAN;
D O I
10.1039/b905668h
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Health care associated infections and deaths have reached dimensions that rival traditional diseases and have become a serious financial burden on the health-care systems. Beyond simple hygiene, hopes are high that new materials capable of killing microorganisms on contact could ease the situation. This review highlights recent trends on surface-modifications capable of eliminating a microbial threat upon contact. Despite significant advances, the field still focuses on chemical synthesis and biological testing without breakthroughs in medical materials research.
引用
收藏
页码:7796 / 7806
页数:11
相关论文
共 92 条
[91]   Current concepts: Prosthetic-joint infections [J].
Zimmerli, W ;
Trampuz, A ;
Ochsner, PE .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (16) :1645-1654
[92]   Antifungal hydrogels [J].
Zumbuehl, Andreas ;
Ferreira, Lino ;
Kuhn, Duncan ;
Astashkina, Anna ;
Long, Lisa ;
Yeo, Yoon ;
Iaconis, Tiffany ;
Ghannoum, Mahmoud ;
Fink, Gerald R. ;
Langer, Robert ;
Kohane, Daniel S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (32) :12994-12998