The global regulator CsrA of Escherichia coli is a specific mRNA-binding protein

被引：142

作者：

Liu, MY

Romeo, T

机构：

[1] UNIV N TEXAS,HLTH SCI CTR,DEPT IMMUNOL & MICROBIOL,FT WORTH,TX 76107

[2] UNIV N TEXAS,HLTH SCI CTR,DEPT BIOCHEM & MOL BIOL,FT WORTH,TX

来源：

JOURNAL OF BACTERIOLOGY | 1997年 / 179卷 / 14期

关键词：

D O I：

10.1128/jb.179.14.4639-4642.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The csrA gene encodes a global regulatory protein which facilitates glgC mRNA decay in vivo. A purified recombinant CsrA protein was found to inhibit in vitro glg (glycogen biosynthesis) gene expression posttranscriptionally and bind specifically to a glgC runoff transcript without causing its decay. Our results provide further insight into the mechanism by which CsrA functions as an mRNA decay factor.

引用

页码：4639 / 4642

页数：4

共 21 条

[11] DISSECTING RNA-PROTEIN INTERACTIONS - RNA-RNA RECOGNITION BY ROP
PREDKI, PF
NAYAK, LM
GOTTLIEB, MBC
REGAN, L
[J]. CELL, 1995, 80 (01) : 41 - 50
[12] *PROM CORP, 1991, PROM PROT APPL GUID
[13] GENETIC AND PHYSICAL MAPPING OF THE REGULATORY GENE CSRA ON THE ESCHERICHIA-COLI K-12 CHROMOSOME
ROMEO, T
GONG, M
[J]. JOURNAL OF BACTERIOLOGY, 1993, 175 (17) : 5740 - 5741
[14] GENETIC-REGULATION OF GLYCOGEN BIOSYNTHESIS IN ESCHERICHIA-COLI - INVITRO EFFECTS OF CYCLIC-AMP AND GUANOSINE 5'-DIPHOSPHATE 3'-DIPHOSPHATE AND ANALYSIS OF INVIVO TRANSCRIPTS
ROMEO, T
PREISS, J
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (05) : 2773 - 2782
[15] GENETIC-REGULATION OF GLYCOGEN BIOSYNTHESIS IN ESCHERICHIA-COLI - INVIVO EFFECTS OF THE CATABOLITE REPRESSION AND STRINGENT RESPONSE SYSTEMS IN GLG-GENE EXPRESSION
ROMEO, T
BLACK, J
PREISS, J
[J]. CURRENT MICROBIOLOGY, 1990, 21 (02) : 131 - 137
[16] IDENTIFICATION AND MOLECULAR CHARACTERIZATION OF CSRA, A PLEIOTROPIC GENE FROM ESCHERICHIA-COLI THAT AFFECTS GLYCOGEN BIOSYNTHESIS, GLUCONEOGENESIS, CELL-SIZE, AND SURFACE-PROPERTIES
ROMEO, T
GONG, M
LIU, MY
BRUNZINKERNAGEL, AM
[J]. JOURNAL OF BACTERIOLOGY, 1993, 175 (15) : 4744 - 4755
[17] Post-transcriptional regulation of bacterial carbohydrate metabolism: Evidence that the gene product CsrA is a global mRNA decay factor
Romeo, T
[J]. RESEARCH IN MICROBIOLOGY, 1996, 147 (6-7) : 505 - 512
[18] PLEIOTROPIC REGULATION OF CENTRAL CARBOHYDRATE-METABOLISM IN ESCHERICHIA-COLI VIA THE GENE CSRA
SABNIS, NA
YANG, HH
ROMEO, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (49) : 29096 - 29104
[19] Sambrook J., 2002, MOL CLONING LAB MANU
[20] Phylogenetic distribution of the global regulatory gene csrA among eubacteria
White, D
Hart, ME
Romeo, T
[J]. GENE, 1996, 182 (1-2) : 221 - 223

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