The role of cyclooxygenase-2 and prostaglandins in colon cancer

被引：81

作者：

Eisinger, Annie L.

Prescott, Stephen M.

Jones, David A.

Stafforini, Diana M.

机构：

[1] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Oncol Sci, Salt Lake City, UT 84112 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2007年 / 82卷 / 1-4期

关键词：

adenomatous polyposis coli; cyclooxygenase-2; colon cancer; Wnt; beta-catenin;

D O I：

10.1016/j.prostaglandins.2006.05.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The temporal association between loss of function of the tumor suppressor adenomatous polyposis coli (APC) and overexpression of cyclooxygenase 2 (COX-2) has been demonstrated in vivo and has led to the hypothesis that APC regulates COX-2 expression. This could potentially occur through a variety of mechanisms including the well-characterized ability of APC to negatively regulate Wnt signaling and decrease expression of target genes. However, recent findings suggest that the products of COX-2 elicit effects that occur upstream of the beta-catenin/TCF/LEF pathway. This review will focus on the regulation of COX-2 by APC and the interplay between COX-2 and the Wnt signaling pathway. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：147 / 154

页数：8

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