[18F]FMDAA1106 and [18F]FEDAA1106:: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR)

被引：87

作者：

Zhang, MR

Maeda, J

Furutsuka, K

Yoshida, Y

Ogawa, M

Suhara, T

Suzuki, K

机构：

[1] Natl Inst Radiol Sci, Dept Med Imaging, Inage Ku, Chiba 2638555, Japan

[2] SHI Accelerator Serv Co Ltd, Shinagawa Ku, Tokyo 1418686, Japan

[3] Japa Sci & Technol Corp, CREST, Kawaguchi 3320012, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(02)00886-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We synthesized and evaluated N-(5-fluoro-2-phenoxyphenyl)-N-(2-[F-18]fluoromethyl-5-methoxybenzyl)acetamide ([F-18]FMDAA1106) and N-(5-fluoro-2-phenoxyphenyl)-N-(2-[F-18]fluoroethyl-5-methoxybenzyl)acetamide ([F-18]FEDAA1106) as two potent radioligands for peripheral benzodiazepine receptors (PBR). [F-18]FMDAA1106 and [F-18]FEDAA1106 were respectively synthesized by fluoroalkylation of the desmethyl precursor DAA1123 with [F-18]FCH2I and [F-18]FCH2CH2Br. Ex vivo autoradiograms of [F-18]FMDAA1106 and [F-18]FEDAA1106 binding sites in the rat brains revealed that a high radioactivity was present in the olfactory bulb, the highest PBR density region in the brain. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：201 / 204

页数：4

共 18 条

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