Determination of HIV drugs in biological matrices: A review

被引：20

作者：

Checa, Antonio ^{[1
]}

Oliver, Ramon ^{[2
]}

Hernandez-Cassou, Santiago ^{[1
]}

Saurina, Javier ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

[2] Univ Politecn Cataluna, Univ Sch Tech Engn Barcelona, Barcelona 08036, Spain

来源：

ANALYTICA CHIMICA ACTA | 2009年 / 647卷 / 01期

关键词：

Antiretroviral drugs; Biological matrices; High-performance liquid chromatography; Ultraviolet detection; Mass spectrometry/mass spectrometry detection; Validation; TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; REVERSE-TRANSCRIPTASE INHIBITORS; BLOOD MONONUCLEAR-CELLS; SOLID-PHASE EXTRACTION; CAPILLARY-ZONE-ELECTROPHORESIS; MS-MS METHOD; HUMAN PLASMA; PROTEASE INHIBITORS; ANTIRETROVIRAL DRUGS;

D O I：

10.1016/j.aca.2009.05.028

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The present paper reviews the recent advances on the determination of antiretroviral drugs against the human immunodeficiency virus (HIV). Methods have been reviewed with special emphasis on the principal analytical strategies for dealing with clinical samples as well as the determination of the newest drugs. The most critical steps of the analytical procedures including the sample treatment, separation and validation have been discussed. Finally, a brief description of representative applications is given. (C) 2009 Elsevier B.V. All rights reserved.

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页码：1 / 13

页数：13

相关论文

共 89 条

[1] An update on therapeutic drug monitoring for antiretroviral drugs [J].

Back, David ;

Gibbons, Sara ;

Khoo, Saye .

THERAPEUTIC DRUG MONITORING, 2006, 28 (03) :468-473

[2]

Balani SK, 1996, DRUG METAB DISPOS, V24, P1389

[3] A strategy for liquid chromatography/tandem mass spectrometric assays of intracellular drugs: application to the validation of the triphosphorylated anabolite of antiretrovirals in peripheral blood mononuclear cells [J].

Becher, F ;

Pruvost, A ;

Gale, J ;

Couerbe, P ;

Goujard, C ;

Boutet, V ;

Ezan, E ;

Grassi, J ;

Benech, H .

JOURNAL OF MASS SPECTROMETRY, 2003, 38 (08) :879-890

[4] Development of a direct assay for measuring intracellular AZT triphosphate in humans peripheral blood mononuclear cells [J].

Becher, F ;

Schlemmer, D ;

Pruvost, A ;

Nevers, MC ;

Goujard, C ;

Jorajuria, S ;

Guerreiro, C ;

Brossette, T ;

Lebeau, L ;

Créminon, C ;

Grassi, J ;

Benech, H .

ANALYTICAL CHEMISTRY, 2002, 74 (16) :4220-4227

[5] Improved method for the simultaneous determination of d4T, 3TC and ddl intracellular phosphorylated anabolites in human peripheral-blood mononuclear cells using high-performance liquid chromatography/tandem mass spectrometry [J].

Becher, F ;

Pruvost, A ;

Goujard, C ;

Guerreiro, C ;

Delfraissy, JF ;

Grassi, J ;

Benech, H .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2002, 16 (06) :555-565

[6] Simultaneous analysis of several antiretroviral nucleosides in rat-plasma by high-performance liquid chromatography with UV using acetic acid/hydroxylamine buffer - Test of this new volatile medium-pH for HPLC-ESI-MS/MS [J].

Bezy, V ;

Morin, P ;

Couerbe, P ;

Leleu, G ;

Agrofoglio, L .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 821 (02) :132-143

[7] Analysis and validation of the phosphorylated metabolites of two anti-human immunodeficiency virus nucleotides (stavudine and didanosine) by pressure-assisted CE-ESI-MS/MS in cell extracts: Sensitivity enhancement by the use of perfluorinated acids and alcohols as coaxial sheath-liquid make-up constituents [J].

Bezy, Vincent ;

Chaimbault, Patrick ;

Morin, Philippe ;

Unger, Steve E. ;

Bernard, Marie-Charlotte ;

Agrofoglio, Luigi A. .

ELECTROPHORESIS, 2006, 27 (12) :2464-2476

[8]

Boffito M, 2005, ANTIVIR THER, V10, P469

[9] Highly sensitive determination of saquinavir in biological samples using liquid chromatography-tandem mass spectrometry [J].

Burhenne, J ;

Riedel, KD ;

Martin-Facklam, M ;

Mikus, G ;

Haefeli, WE .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 784 (02) :233-242

[10]

Cahours X, 2002, ELECTROPHORESIS, V23, P88, DOI 10.1002/1522-2683(200201)23:1<88::AID-ELPS88>3.0.CO

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