Thermal effects of focused ultrasound on the brain: Determination with MR imaging

被引:162
作者
Hynynen, K [1 ]
Vykhodtseva, NI [1 ]
Chung, AH [1 ]
Sorrentino, V [1 ]
Colucci, V [1 ]
Jolesz, FA [1 ]
机构
[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115
关键词
brain; US; magnetic resonance (MR); guidance; temperature monitoring; ultrasound; (US); therapeutic;
D O I
10.1148/radiology.204.1.9205255
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To determine the feasibility of the use of temperature-sensitive magnetic resonance (MR) imaging for the detection of local temperature elevations at the focus of a low-power ultrasound beam in the brain. MATERIALS AND METHODS: The brains in 28 rabbits were sonicated at acoustic power levels of 3.5-17.5 W. Four to five different locations were sonicated at different acoustic power levels in each rabbit. MR images were obtained 2 hours, 48 hours, 10 days, and 23 days after the sonications, depending on when the animals were sacrificed. Histologic evaluation of whole brain was performed. RESULTS: Forty of 43 (93%) of the lowest-power (3.5-W) sonications were visible on temperature-sensitive MR images and did not result in any short- or long-term histologic or MR imaging evidence of tissue damage. A contrast-to-noise ratio of approximately 6 and a temperature elevation of 7 degrees-8 degrees C were observed. CONCLUSION: Temperature elevations induced by means of focused ultrasound exposures that do not cause damage in the in vivo rabbit brain can be detected at temperature-sensitive MR imaging.
引用
收藏
页码:247 / 253
页数:7
相关论文
共 36 条
[1]   HIGH-INTENSITY FOCUSED ULTRASOUND IN THE TREATMENT OF PROSTATIC TISSUE [J].
BIHRLE, R ;
FOSTER, RS ;
SANGHVI, NT ;
FRY, FJ ;
DONOHUE, JP .
UROLOGY, 1994, 43 (02) :21-26
[2]   EFFECTS OF PHYSICAL PARAMETERS ON HIGH-TEMPERATURE ULTRASOUND HYPERTHERMIA [J].
BILLARD, BE ;
HYNYNEN, K ;
ROEMER, RB .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1990, 16 (04) :409-420
[3]   ACOUSTIC PROPERTIES OF LESIONS GENERATED WITH AN ULTRASOUND THERAPY SYSTEM [J].
BUSH, NL ;
RIVENS, I ;
TERHAAR, GR ;
BAMBER, JC .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1993, 19 (09) :789-801
[4]   Optimization of spoiled gradient-echo phase imaging for in vivo localization of a focused ultrasound beam [J].
Chung, AH ;
Hynynen, K ;
Colucci, V ;
Oshio, K ;
Cline, HE ;
Jolesz, FA .
MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) :745-752
[5]   FOCUSED US SYSTEM FOR MR IMAGING-GUIDED TUMOR ABLATION [J].
CLINE, HE ;
HYNYNEN, K ;
WATKINS, RD ;
ADAMS, WJ ;
SCHENCK, JF ;
ETTINGER, RH ;
FREUND, WR ;
VETRO, JP ;
JOLESZ, FA .
RADIOLOGY, 1995, 194 (03) :731-737
[6]  
Doss J D, 1976, Med Instrum, V10, P16
[7]   THE EFFECTS OF CURVED TISSUE LAYERS ON THE POWER DEPOSITION PATTERNS OF THERAPEUTIC ULTRASOUND BEAMS [J].
FAN, XB ;
HYNYNEN, K .
MEDICAL PHYSICS, 1994, 21 (01) :25-34
[8]   THE EFFECT OF WAVE REFLECTION AND REFRACTION AT SOFT-TISSUE INTERFACES DURING ULTRASOUND HYPERTHERMIA TREATMENTS [J].
FAN, XB ;
HYNYNEN, K .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1992, 91 (03) :1727-1736
[9]   DETERMINATION OF ABSOLUTE SOUND LEVELS AND ACOUSTIC ABSORPTION COEFFICIENTS BY THERMOCOUPLE PROBES - EXPERIMENT [J].
FRY, WJ ;
FRY, RB .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1954, 26 (03) :311-317
[10]   ULTRASONIC LESIONS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM [J].
FRY, WJ ;
BARNARD, JW ;
FRY, FJ ;
KRUMINS, RF ;
BRENNAN, JF .
SCIENCE, 1955, 122 (3168) :517-518