Minireview: Delivering the Code: Polyplex Carriers for Deoxyribonucleic Acid and Ribonucleic Acid Interference Therapies

被引：61

作者：

Christie, R. James ^{[1
]}

Nishiyama, N. ^{[2
,3
,4
]}

Kataoka, K. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Tokyo, Dept Mat Engn, Tokyo 1138656, Japan

[2] Univ Tokyo, Grad Sch Engn, Tokyo 1138656, Japan

[3] Univ Tokyo, Ctr NanoBio Integrat, Tokyo 1138656, Japan

[4] Univ Tokyo, Ctr Dis Biol & Integrat Med, Grad Sch Med, Tokyo 1130033, Japan

[5] Japan Sci & Technol Agcy, Kawaguchi, Saitama 3320012, Japan

来源：

ENDOCRINOLOGY | 2010年 / 151卷 / 02期

关键词：

INTRACELLULAR GENE DELIVERY; ABC TRIBLOCK COPOLYMER; IN-VIVO; POLY(ETHYLENE IMINE); BLOCK-COPOLYMER; MOLECULAR-WEIGHT; SIRNA DELIVERY; DNA COMPLEXES; PLASMID DNA; MACROMOLECULAR THERAPEUTICS;

D O I：

10.1210/en.2009-1045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nucleic acid-based therapies offer great potential for treatment of a variety of diseases including cancer by modulating protein expression with DNA or small interfering RNA. However, realization of their full therapeutic potential is currently limited due to an inability to reach the target site in an active form. Identification of delivery barriers such as stability in circulation, resistance to degradation and entrapment in subcellular vesicles has led to development of sophisticated multifunctional synthetic polymers for forming ionic complexes with nucleic acids and also providing performance-enhancing features. The most promising designs comprise features to help increase stability in circulation and also contain functionality to aid in endosome escape of nucleic acid cargo after cellular internalization. (Endocrinology 151: 466-473, 2010)

引用

页码：466 / 473

页数：8

共 64 条

[21] Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS [J].