In vitro activities of membrane-active peptides alone and in combination with clinically used antimicrobial agents against Stenotrophomonas maltophilia

被引：37

作者：

Giacometti, A ^{[1
]}

Cirioni, O ^{[1
]}

Del Prete, MS ^{[1
]}

Barchiesi, F ^{[1
]}

Fortuna, M ^{[1
]}

Drenaggi, D ^{[1
]}

Scalise, G ^{[1
]}

机构：

[1] Univ Ancona, Inst Infect Dis & Publ Hlth, Ancona, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 06期

关键词：

D O I：

10.1128/AAC.44.6.1716-1719.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of buforin ZI, cecropin P1, and magainin IF, alone and in combination with six clinically used antimicrobial agents, against 12 clinical isolates of Stenotrophomonas maltophilia were investigated. Antimicrobial activities were measured by MIC and time-kill studies. The isolates were susceptible to the peptides at concentrations in the range of 0.50 to 16 mu g/ml. Synergy was observed when the peptides were combined with polymyxin E, meropenem, ceftazidime, piperacillin, and clarithromycin.

引用

页码：1716 / 1719

页数：4

共 23 条

[1] Multiple antibiotic resistance in Stenotrophomonas maltophilia
Alonso, A
Martinez, JL
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) : 1140 - 1142
[2] ANTIMICROBIAL PEPTIDES - A FAMILY OF WOUND HEALERS
CANNON, M
[J]. NATURE, 1987, 328 (6130) : 478 - 478
[3] Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples
Denton, M
Todd, NJ
Kerr, KG
Hawkey, PM
Littlewood, JM
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (07) : 1953 - 1958
[4] Eliot WA, 1996, IEEE SPECTRUM, V33, P8
[5] FALLA TJ, 1996, J BIOL CHEM, V271, P10298
[6] George AM, 1996, FEMS MICROBIOL LETT, V139, P1, DOI 10.1016/0378-1097(96)00127-9
[7] Antibiotic susceptibility among aerobic gram-negative bacilli in intensive care units in 5 European countries
Hanberger, H
Garcia-Rodriguez, JA
Gobernado, M
Goossens, H
Nilsson, LE
Struelens, MJ
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (01): : 67 - 71
[8] Hancock REW, 1997, J MED MICROBIOL, V46, P1
[9] Peptide antibiotics
Hancock, REW
Chapple, DS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) : 1317 - 1323
[10] Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative gram-negative bacteria
Hancock, REW
[J]. CLINICAL INFECTIOUS DISEASES, 1998, 27 : S93 - S99

← 1 2 3 →