An overview of RNAs with regulatory functions in gram-positive bacteria

被引:79
作者
Romby, Pascale [2 ]
Charpentier, Emmanuelle [1 ,3 ]
机构
[1] Umea Univ, Lab Mol Infect Med Sweden, S-90187 Umea, Sweden
[2] Univ Strasbourg, Architecture & React ARN, CNRS, IBMC, F-67084 Strasbourg, France
[3] Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria
基金
奥地利科学基金会; 瑞典研究理事会;
关键词
Regulatory RNAs; Small RNAs; Noncoding RNAs; Riboswitches; CRISPR; Gene expression regulation; Virulence; Gram-positive bacteria; SIGNAL RECOGNITION PARTICLE; SMALL NONCODING RNAS; MEDIATED TRANSCRIPTIONAL ATTENUATION; STAPHYLOCOCCUS-AUREUS RNAIII; PROVIDES ACQUIRED-RESISTANCE; ENCODED ANTISENSE RNA; BINDING PROTEIN HFQ; BACILLUS-SUBTILIS; MESSENGER-RNA; LISTERIA-MONOCYTOGENES;
D O I
10.1007/s00018-009-0162-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During the last decade, RNA molecules with regulatory functions on gene expression have benefited from a renewed interest. In bacteria, recent high throughput computational and experimental approaches have led to the discovery that 10-20% of all genes code for RNAs with critical regulatory roles in metabolic, physiological and pathogenic processes. The trans-acting RNAs comprise the noncoding RNAs, RNAs with a short open reading frame and antisense RNAs. Many of these RNAs act through binding to their target mRNAs while others modulate protein activity or target DNA. The cis-acting RNAs include regulatory regions of mRNAs that can respond to various signals. These RNAs often provide the missing link between sensing changing conditions in the environment and fine-tuning the subsequent biological responses. Information on their various functions and modes of action has been well documented for gram-negative bacteria. Here, we summarize the current knowledge of regulatory RNAs in gram-positive bacteria.
引用
收藏
页码:217 / 237
页数:21
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