Increased Oxidative Stress and Cardiomyocyte Myofibrillar Degeneration in Patients With Chronic Isolated Mitral Regurgitation and Ejection Fraction >60%

被引：116

作者：

Ahmed, Mustafa I. ^{[2
,3
,4
]}

Gladden, James D. ^{[2
,3
,4
]}

Litovsky, Silvio H. ^{[2
,3
,4
]}

Lloyd, Steven G. ^{[2
,3
,4
]}

Gupta, Himanshu ^{[2
,3
,4
]}

Inusah, Seidu ^{[2
,3
,4
]}

Denney, Thomas, Jr. ^{[6
]}

Powell, Pamela ^{[2
,3
,4
]}

McGiffin, David C. ^{[2
,3
,4
]}

Dell'Italia, Louis J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] UAB, Ctr Heart Failure Res, Div Cardiol, Dept Med, Birmingham, AL 35294 USA

[2] UAB, Ctr Heart Failure Res, Dept Cardiovasc Surg, Birmingham, AL 35294 USA

[3] UAB, Ctr Heart Failure Res, Dept Pathol, Birmingham, AL 35294 USA

[4] UAB, Ctr Heart Failure Res, Dept Biostat, Birmingham, AL 35294 USA

[5] Birmingham Vet Affairs Med Ctr, Birmingham, AL USA

[6] Auburn Univ, Samuel Ginn Coll Engn, Auburn, AL 36849 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2010年 / 55卷 / 07期

关键词：

mitral regurgitation; oxidative stress; magnetic resonance imaging; tissue tagging; LEFT-VENTRICULAR FUNCTION; VALVE REPAIR; XANTHINE OXIDOREDUCTASE; HUMAN FIBROBLASTS; WALL STRESS; EXERCISE; RECONSTRUCTION; REPLACEMENT; DYSFUNCTION; INHIBITION;

D O I：

10.1016/j.jacc.2009.08.074

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives This study assessed myocardial damage in patients with chronic isolated mitral regurgitation (MR) and left ventricular ejection fraction (LVEF) > 60%. Background Typically, MR patients have decreased LVEF after mitral valve (MV) repair despite normal pre-operative LVEF. Methods Twenty-seven patients with isolated MR had left ventricular (LV) biopsies taken at time of MV repair. Magnetic resonance imaging with tissue tagging was performed in 40 normal subjects and in MR patients before and 6 months after MV repair. Results LVEF (66 +/- 5% to 54 +/- 9%, p < 0.0001) and LV end-diastolic volume index (108 +/- 28 ml/m(2) to 78 +/- 24 ml/m(2), p < 0.0001) decreased, whereas left ventricular end-systolic (LVES) volume index was 60% above normal pre- and post-MV repair (p < 0.05). The LV circumferential and longitudinal strain rates decreased below normal following MV repair (6.38 +/- 1.38 vs. 5.11 +/- 1.28, p = 0.0009, and 7.51 +/- 2.58 vs. 5.31 +/- 1.61, percentage of R to R interval, p < 0.0001), as LVES stress/LVES volume index ratio was depressed at baseline and following MV repair versus normal subjects (0.25 +/- 0.10 and 0.28 +/- 0.05 vs. 0.33 +/- 0.12, p < 0.01). LV biopsies demonstrated cardiomyocyte myofibrillar degeneration versus normal subjects (p = 0.035). Immunostaining and immunoblotting demonstrated increased xanthine oxidase in MR versus normal subjects (p < 0.05). Lipofuscin deposition was increased in cardiomyocytes of MR versus normal subjects (0.62 +/- 0.20 vs. 0.33 +/- 0.11, percentage of area: p < 0.01). Conclusions Decreased LV strain rates and LVES wall stress/LVES volume index following MV repair indicate contractile dysfunction, despite pre-surgical LVEF > 60%. Increased oxidative stress could cause myofibrillar degeneration and lipofuscin accumulation resulting in LV contractile dysfunction in MR. (J Am Coll Cardiol 2010;55:671-9) (C) 2010 by the American College of Cardiology Foundation

引用

页码：671 / 679

页数：9

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Increased Oxidative Stress and Cardiomyocyte Myofibrillar Degeneration in Patients With Chronic Isolated Mitral Regurgitation and Ejection Fraction &gt;60%

Increased Oxidative Stress and Cardiomyocyte Myofibrillar Degeneration in Patients With Chronic Isolated Mitral Regurgitation and Ejection Fraction >60%