Nerve Growth Factor Attenuates Proliferation of Astrocytes via the p75 Neurotrophin Receptor

被引：67

作者：

Cragnolini, Andrea B. ^{[1
]}

Huang, Yangyang ^{[1
]}

Gokina, Pradeepa ^{[1
]}

Friedman, Wilma J. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Biol Sci, Newark, NJ 07102 USA

来源：

GLIA | 2009年 / 57卷 / 13期

关键词：

NGF; seizures; cell cycle; AFFINITY NGF RECEPTOR; CELL-CYCLE PROGRESSION; FACTOR MESSENGER-RNA; SIGNAL-TRANSDUCTION; HIPPOCAMPAL-NEURONS; P75-MEDIATED DEATH; RAT ASTROCYTES; CNS INJURY; IN-VIVO; EXPRESSION;

D O I：

10.1002/glia.20857

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75 R is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these glial cells has not been defined. We have employed a primary culture system to investigate the effects of neurotrophins on astrocytes. Treatment of hippocampal astrocytes with nerve growth factor (NGF) caused a reduction in cell number, but did not elicit an apoptotic response, in contrast to hippocampal neurons. Instead, activation of p75(NTR) by NGF attenuated proliferation induced by mitogens such as EGF or serum. These studies demonstrate the cell type specificity of neurotrophin functions in the brain. (C) 2009 Wiley-Liss, Inc.

引用

页码：1386 / 1392

页数：7

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